High Street South, as its name suggests, lies to the South of Rushden's main High Street. As one approaches Rushden from the South, on the main A6 from Bedford, the road becomes High Street South at Little Street. Businesses along High Street South are situated both to the East and West side of the road. They are listed below in order starting from near the town centre and heading South. Note that, due to their close proximity to High Street South, businesses in The Precinct, Griffith Street and Little Street are included in this list.

High Street South (West side):	High Street South (East side):
Edmund Chan Dental Surgery	Wheatsheaf Hotel
Teze Indian Restaurant	Domino's Pizza
Thai In Restaurant	Bailey & Black Estate Agents
Imperial Garden Take-Away	CLD Cleaning Services
Barry Miller (Hairdresser)	Blue Corner Cars
Conservative Club	Taylor Griffin Estate Agents
I & J Freij Newsagents	Park View Beauty (Griffith Street)
	Commerce Windows (Griffith Street)
	Manfield Crafts (Griffith Street)
	Rushden Working Men's Club (Griffith Street)
	Visage Denture Repairs
	Aitch Recruitment
	Stitches (Dressmakers)
	Texas Longhorn
	Hair Studio
	Fish & Chip Shop
	Grand Indian Take-Away
	Dragon City
	Rushden Osteopathic Clinic
	Zees Second Hand Domestic Appliances
	Rushden Fitness & Health Centre (Little Street)
	The Compasses
	Abbotts Funeral Drectors
	D W Sherwood Antiques (Little Street)
The Precinct 1970s	Steve Horsley Motors (Bedford Road)